WR Hambrecht+Co was founded by William Hambrecht, who previously founded investment bank Hambrecht & Quist that went public in 1996 and was acquired by Chase Manhattan in 1999. For more than 50 years Hambrecht has been renowned for identifying early disruptive companies and helping them grow.

In the 1990s Hambrecht also began a series of collaborations with Harvard Professor Clayton Christensen, leading WR Hambrecht+Co to adopt an investment strategy based on a disciplined application of Christensen's research.

Ongoing refinement of this approach resulted in the Market Exaptation Simulation Engine ('MESE®'), an advanced computing and big data platform that has continued to evolve for more than a decade. MESE® provides unique insights into private markets with an ability to pinpoint early disruptive companies around the globe.